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Yang CJ, Chang HC, Sung PC, et al
Research-grade peptides purchased online are not subject to MHRA manufacturing standards and may be contaminated, mislabelled, or incorrectly dosed
Nonetheless, individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their clinician before enrolling in any trial involving this class of agent
Since in some of the studies analysed type 2 diabetic patients were treated with metformin, which has been shown to enhance GLP-1 responses [51], any potential difference in GLP-1 secretory responses between type 2 diabetic patients and healthy participants may have been modified by this mechanism
Less common but important risks include gallbladder disease, pancreatitis, and the boxed warning for medullary thyroid carcinoma based on rodent data
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